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The acute form of brucellosis is characterized by pain and stiffness in the joints, muscle soreness.
In chronic brucellosis, local severe lesions of the joints in the form of Levothyroxine pill arthritis are observed. With brucellosis, changes are found in large joints and joints. There are osteomyelitis, spondylitis, ankylosis, peri- and paraarthritis, tendovaginitis, synovitis, bursitis, fibrositis (painful compaction of the connective tissue).
The peripheral nervous system is often affected (neuritis, plexitis, radiculitis), less often the central nervous system (meningitis, encephalitis, arachnoiditis, etc.). The cardiovascular system also suffers to a large extent, with a predominant lesion of peripheral vessels.
Hepato-lienal syndrome is typical. In men, orchitis, epididymitis are not uncommon, in women - salpingitis, oophoritis, dysmenorrhea, metritis. In the acute period of brucellosis, pregnancy can end in spontaneous miscarriage. Pregnancy often worsens the course of brucellosis, exacerbates it. After one and a half to two years from the onset of the disease, the pregnancy proceeds normally, the child is born healthy. However, in this period, premature birth, stillbirth, etc. are described.
Diagnosis of brucellosis is based on clinical and epidemiological data. An epidemiological history is a significant help in making a diagnosis (profession, contact with sick animals, consumption of infected products, etc.).Read more
For the diagnosis of brucellosis, the complement fixation reaction (RCC), the opson-phagocytic reaction, is also used.
In recent years, the reaction of passive hemagglutination (RPHA), the determination of the titer of opsonins, the method of immunofluorescence, etc. have been developed and proposed. The intradermal allergic diagnostic test of Burne, which is placed with brucellin and is highly sensitive, is widely used, is detected in the first month of the disease and can persist even after recovery.Read more
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